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Methyl p-chlorocinnamate

Methyl p-chlorocinnamate is an organic chemical, often used in industry, pharmaceutical industry, etc., obtained by reacting chlorobenzaldehyde with acetic anhydride. The chlorobenzene formaldehyde, acetic anhydride and sodium acetate with reaction 13h under 180 ℃. After the reaction, it is slightly cold. Pour into the water, filter and wash the filter cake with water. Dissolve the cake repeatedly with ammonia until only a small amount of brownish-yellow sticky remains remain. The ammonium salt solution was filtered, then the chlorocinnamic acid was precipitated out with 3N dilute sulfuric acid, and the product was filtered and dried. 

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Specifications

Name: Methyl p-chlorocinnamate
Synonyms: Methyl 4-chlorocinnamate; 4-Chlorocinnamic Acid Methyl Ester; methyl 3-(4-chlorophenyl)prop-2-enoate; 4-Chlorocinnamic Acid Methyl Ester
CAS No: 7560-44-3
Molecular formula: C10H9ClO2
Melting point: 196.5
Assay: ≥99%
Description: White Crystalline Powder
Heavy metal content: 10 ppm
Physicochemical property: White Crystalline Powder, it can disolve in ethyl alcohol and diethyl ether, can't disolve in water.
Preparation method: Obtained by reacting chlorocinnamic acid with methanol in the presence of concentrated sulfuric acid
Storage condition: Seal in a cool, dry environment
Stability: If used and stored according to specifications, it will not decompose.

Application

Methyl p-chlorocinnamate is an organic synthesis intermediate, mainly used to synthesize methyl bromomethyl cinnamate from the upstream raw material of the antithrombotic agent ozagrel sodium. The methyl methylanilate was prepared by N- butyl diimide bromide bromide and the total yield was 67%.