Alpha-Methylcinnamaldehyde is a versatile fragrance commonly used in the fragrance of cosmetics, soaps, foods, etc. The Alpha-methyl streptopropane obtained by the further reaction thereof is used as a synthetic essence and also has a very good aroma. At the same time, α-methylcinnamaldehyde is also an important intermediate for the synthesis of the therapeutic drug epalrestat. As the number of diabetic patients increases, the demand for the drug increases, and the demand for intermediates also increases, and there is an urgent need to improve the process to improve quality.
Synonyms: 2-methyl-3-phenyl-2-propena; 2-Methyl-3-phenylacrylaldehyde; 2-methyl-3-phenyl-prop-2-enal; 2-propenal,2-methyl-3-phenyl-; alpha-methyl-cinnamaldehyd; alpha-Methylcinnimal
Chemical formula: C10H10O
Molecular weight: 146.19
CAS NO: 101-39-3
EINECS NO: 202-938-8
Boiling point: 148- 149ºC/3.05KPa.
Density: 1.047g/ml at 25ºC
Refractive index: 1.605-1.607
Flash point: 79ºC
Appearance: Yellow liquid, smell sweet
Stability: Stable, Combustible, Incompatible with strong oxidizing agents, strong bases.
Solubility: Soluble in ethanol, propylene glycol and non-volatile oil, insoluble in glycerin and water. Avoid touch with skin and eyes when using.
Storage: Keep the container closed and store in a dry, well-ventilated place.
Reactivity Profile: Alpha-Methylcinnamaldehyde is incompatible with strong oxidizing agents and strong bases.
Fire Hazard: Alpha-Methylcinnamaldehyde is combustible.
The chemical name of alpha-methylcinnamic acid is alpha-methylphenylacrolein, which is an important fine chemical intermediate and is widely used in the production of pharmaceuticals, spices and other products. At present, there are several methods for preparing alpha-methylcinnamaldehyde. 1. Benzoaldehyde and n-propanal are used as raw materials, KF/A1203 is used as a catalyst, and polyethylene glycol is a phase transfer solution to synthesize ct-methyl cinnamaldehyde. The yield is 78.9. %. The yield of alpha-methylcinnamaldehyde synthesized by the method is high, and the process is relatively simple, but the preparation of the catalyst used is complicated, expensive, and has a little pollution to the environment, and the recycling process is cumbersome. 2, using benzaldehyde and n-propionaldehyde as raw materials, ethanol as solvent, PEG400, PEG600 for phase transfer synthesis of a-methyl cinnamaldehyde, the yield is 54.2%, the alpha-methyl cinnamaldehyde synthesized by this method has more negative reaction, product separation It is difficult to purify; 3, using benzaldehyde and n-propionaldehyde as raw materials, ethanol as solvent, TBAB as phase transfer catalyst, synthesizing a-methyl cinnamaldehyde under alkaline medium, the yield is 59.7%, the a-form synthesized by this method The synthesis process of cinnamaldehyde is simple, but the conversion rate of the raw material reaction is low, and the negative reaction is high, resulting in low product yield.
Summary of the invention
The object of the present invention is to provide a method for preparing alpha-methylcinnamaldehyde, which comprises synthesizing a-formaldehyde with benzaldehyde and n-propanal in an alkaline medium and using an aqueous solution of methanol as a solvent. The cinnamaldehyde has simple method, convenient operation, low raw material cost, high yield and no pollution to the environment, and is very suitable for industrial production.
Appear: Colorless to pale yellow transparent liquid (est) Melting point : 262.00 to 265.00 °C. @ 760.00mmHg Flash point: 110.5°C Steam pressure: 0.011000 mm / Hg at 20.00 °C. Refractive Index (25 Degree C ): 1.540-1.543 Assay: 98.5% min Shelf Life: 24.00 month(s) or longer if stored properly. storage: Store in a cool dry place, sealed in a c
(E)-3-(3-Chlorophenyl)propenoic acid; 3-Chloro-trans-cinnamic acid; m-Chloro-trans-cinnamic acid; (E)-3-(3-Chlorophenyl)acrylic acid, (2E)-3-(3-Chlorophenyl)prop-2-enoic acid; trans-3-Chlorocinnamic acid 98%;(E)-3-Chlorocinnamic Acid; trans-3-Chlorocinnamicacid98%; 3-(3-chlorophenyl)-,(E)-2-Propenoicacid
Appearance: Pale yellow liquid/colorless thick liquid, solid when cold. Fragrant, sweet amber and fresh fruit. Solubility: Insoluble in water, soluble in oil, miscible in ethanol. Package specification: 200kg/blue barrel Storage: Pay attention to the source of fire, especially to avoid sunlight, and store in a cool place.
Appearance: Pale yellow liquid/colorless thick liquid, solid when cold. Solubility: Miscible in ethanol, ether, chloroform and most non-volatile oils, soluble in propylene glycol, insoluble in water。 Vapor pressure: 0.00141mmHg at 25°C Package specification: 200kg/blue barrel Storage: Keep the reservoir sealed. Put in a tight storage and stor