4-methyl cinnamic acid methyl ester is a important items which mainly used in cosmetics. At present, there is a new method to produce 4-methyl cinnamic acid methyl ester, which has the advantages of low raw material cost, mild reaction condition, and methyl p-methylcinnamate obtained by one-step reaction, and the method is simple, easy to operate, high in yield, stable and reliable in product quality, and non-polluting to the environment, is a kind of green The method of synthesizing fragrance.
Name: 4-methyl cinnamic acid methyl ester
Alias: METHYL 4-METHYLCINNAMATE; Methyl trans-4-methylcinnamate; Methyl 3-(p-tolyl)acrylate; methyl (E)-3-(4-methylphenyl)prop-2-enoate
Molecular formula: C11H12O2
Molecular weight: 176.21
Melting Point: 60-61 ℃
Boiling point: 272.9 degree C at 760 mmHg
Appearance: White to light yellow crystalline powder
Acid value(mgKOH/g): Is no more than 3.0
4-methyl cinnamic acid methyl ester is a pharmaceutical intermediate. It is mainly used for the synthesis of methyl bromomethylcinnamate, the upstream raw material of the antithrombotic drug Ozagrel sodium. Methyl p-methylcinnamate is brominated by N-bromosuccinimide to obtain methyl p-bromomethylcinnamate, methyl p-bromomethylcinnamate in ionic liquid N-n-butylpyridine tetrafluoroboron The acid salt was lyophilized with imidazole at room temperature and then hydrolyzed to obtain an antithrombotic drug, ozagrel sodium, with a total yield of 67%. Methyl p-methylcinnamate is first reacted with p-methylbenzaldehyde and malonic acid to form p-methylcinnamic acid, which is then esterified with p-methylcinnamic acid and methanol to form methyl p-methylcinnamate.
Appearance: Pale yellow liquid/colorless thick liquid, solid when cold. Fragrant, sweet amber and fresh fruit. Solubility: Insoluble in water, soluble in oil, miscible in ethanol. Package specification: 200kg/blue barrel Storage: Pay attention to the source of fire, especially to avoid sunlight, and store in a cool place.