4-methyl cinnamic acid methyl ester is a important items which mainly used in cosmetics. At present, there is a new method to produce 4-methyl cinnamic acid methyl ester, which has the advantages of low raw material cost, mild reaction condition, and methyl p-methylcinnamate obtained by one-step reaction, and the method is simple, easy to operate, high in yield, stable and reliable in product quality, and non-polluting to the environment, is a kind of green The method of synthesizing fragrance.
Name: 4-methyl cinnamic acid methyl ester
Alias: METHYL 4-METHYLCINNAMATE; Methyl trans-4-methylcinnamate; Methyl 3-(p-tolyl)acrylate; methyl (E)-3-(4-methylphenyl)prop-2-enoate
Molecular formula: C11H12O2
Molecular weight: 176.21
Melting Point: 60-61 ℃
Boiling point: 272.9 degree C at 760 mmHg
Appearance: White to light yellow crystalline powder
Acid value(mgKOH/g): Is no more than 3.0
4-methyl cinnamic acid methyl ester is a pharmaceutical intermediate. It is mainly used for the synthesis of methyl bromomethylcinnamate, the upstream raw material of the antithrombotic drug Ozagrel sodium. Methyl p-methylcinnamate is brominated by N-bromosuccinimide to obtain methyl p-bromomethylcinnamate, methyl p-bromomethylcinnamate in ionic liquid N-n-butylpyridine tetrafluoroboron The acid salt was lyophilized with imidazole at room temperature and then hydrolyzed to obtain an antithrombotic drug, ozagrel sodium, with a total yield of 67%. Methyl p-methylcinnamate is first reacted with p-methylbenzaldehyde and malonic acid to form p-methylcinnamic acid, which is then esterified with p-methylcinnamic acid and methanol to form methyl p-methylcinnamate.
Appearance: Pale yellow liquid/colorless thick liquid, solid when cold. Solubility: Miscible in ethanol, ether, chloroform and most non-volatile oils, soluble in propylene glycol, insoluble in water。 Vapor pressure: 0.00141mmHg at 25°C Package specification: 200kg/blue barrel Storage: Keep the reservoir sealed. Put in a tight storage and stor
P-Hydroxycinnamic Acid, also known as 4-Hydroxycinnamic acid, is a radical scavenging effects of antioxidant, compared with other tyrosinase inhibitor, the hydroxy cinnamic acid and ether hydroxy cinnamic acid and other non-toxic odorless, good permeability, and is considered a good candidate material used as a skin whitening agent.
(E)-3-(3-Chlorophenyl)propenoic acid; 3-Chloro-trans-cinnamic acid; m-Chloro-trans-cinnamic acid; (E)-3-(3-Chlorophenyl)acrylic acid, (2E)-3-(3-Chlorophenyl)prop-2-enoic acid; trans-3-Chlorocinnamic acid 98%;(E)-3-Chlorocinnamic Acid; trans-3-Chlorocinnamicacid98%; 3-(3-chlorophenyl)-,(E)-2-Propenoicacid
Appear: Colorless to pale yellow transparent liquid (est) Melting point : 262.00 to 265.00 °C. @ 760.00mmHg Flash point: 110.5°C Steam pressure: 0.011000 mm / Hg at 20.00 °C. Refractive Index (25 Degree C ): 1.540-1.543 Assay: 98.5% min Shelf Life: 24.00 month(s) or longer if stored properly. storage: Store in a cool dry place, sealed in a c
Appearance: A colorless, transparent liquid with a sweet, fruity and oily taste. Solubility: Miscible in ethanol, ether, chloroform and most non-volatile oils, soluble in propylene glycol, insoluble in water. Vapor pressure: 0.00141mmHg at 25°C Package specification: 200kg/blue barrel Storage: Pay attention to the source of fire, especially to